Research Associate - Open Rank

POSITION SUMMARY:

Under the direction of the Principal Investigator (PI) or designee, the Research Associate provides operational support to the laboratory. The Research Associate will perform research experiments as defined by the PI.

This is an open-rank posting (there are 4 levels of Research Associate) - candidates will be hired into the level commensurate with their experience.

The Bondeson Lab is looking for a motivated and talented Research Associate to join our newly formed team. This position affords the exciting opportunity to contribute to biomedical research projects aimed at uncovering the fundamental processes that allow life to adapt to its environment and their dysregulation in disease, particularly cancer. The Bondeson Lab, opened in Fall 2024, leverages chemical biology (e.g. targeted protein degradation) and functional genomics (e.g. CRISPR/Cas9-based screens) to interrogate these biological systems and translate these findings to benefit patients. Within an environment that prioritizes its peoples' growth as much as their scientific output, this is the perfect opportunity for a candidate with several years of laboratory experience to independently lead research projects and contribute to the training environment of the lab as a scientific leader. The ideal candidate will be given opportunities to develop their own ideas from initial concepts towards publications. Find more information about the Bondeson Lab at bondesonlab.org. Please include a brief letter of interest (cover letter) in your application.

ESSENTIAL FUNCTIONS:

Research Associate I:

Perform laboratory experiments and may be responsible for a single research project.
• Utilize all software relevant to experiment and equipment used.
• Interpret data, form conclusions and decide on next steps under the direction of the PI or designee.
• Maintain accurate records, may modify protocols with the approval of the PI or designee.
• Review literature, publications and grants relevant to assigned projects.
• Record results according to established lab, sponsor & university protocol
• Assist with performing data analysis and/or mathematical computations.
• Maintain a detailed lab notebook according to lab practice.
• Present findings at lab/group meetings
• Monitor laboratory supply levels and order as noted.
• Prepare and label buffers, media, solutions, etc.
• Assist with and comply with all safety regulation and infection control standards.
• Train on IACUC, IRB, EHS, Radiation safety protocols
• Comply with all applicable state, federal university, and sponsor policies and agreements.
• Provide support with identifying problems and challenges, propose resolutions, implement appropriate solutions.
• Provide support with drafting standard operation procedures in compliance to EHS regulation specific for the lab.
• Perform other duties as required.

Research Associate II:

Duties noted above plus:

• May assist with the training of new lab personnel.
• Provide support with drafting standard operation procedures in compliance to EHS regulation specific for the lab.
• May assist with drafting manuscript sessions.

Research Associate III:

Duties noted above plus:

• Perform complex laboratory experiments and may be responsible for one or more independent research projects.
• Perform in-depth data analysis and/or mathematical computations.
• Compile and analyze data and present it in a format suitable for publication according to PI specifications.
• May oversee laboratory supply levels and order as needed; negotiate with suppliers to optimize available resources.
• Monitor laboratory equipment service contracts and monitor maintenance on laboratory equipment.
• May manage general operations of the laboratory, including lab personnel, procedures, and projects.
• May create new protocols and/or modify defined protocols, as necessary, and with the approval of the PI.
• Prioritize and perform several tasks or procedures simultaneously with attention to detail.
• Perform duties and experiments with independence.
• Provide training of new lab personnel.
• May monitor laboratory spending in accordance with budget guidelines provided by PI or designee.
• May assist with budget and/or operational aspects of grant and contract funding.

Research Associate IV:

Duties noted above plus:

• This position will contribute significantly to the management of the research program and will be involved in multiple aspects of the research projects and lab maintenance activities.
• Independently design and perform multiple complex laboratory experiments.
• Interpret data, form conclusions, and decide on next steps with a high degree of independence.
• Maintain laboratory supply levels and order as noted.
• Manage laboratory equipment service contracts and coordinate maintenance on laboratory equipment.
• Monitor and enforce all safety regulations and infection control standards.
• Identify and write standard operation procedures in compliance to EHS regulation specific for the lab
• Train on IACUC, EHS, Radiation safety protocols
• Manage daily operations of the laboratory, including lab personnel, procedures, and projects.
• Identify problems and challenges, propose resolutions, implement appropriate solutions.
• Develop and implement new protocols and/or modify defined protocols, as necessary, and with the approval of the PI
• Mentor and train lab personnel on proper lab conduct and techniques.
• Manage laboratory spending in accordance with budget guidelines provided by PI or designee.
• Assist with budget and/or operational aspects of grant and contract proposals.
• Negotiate with vendors to optimize available resources.
• Contribute independently to writing sections for manuscripts and grants.
• Direct the activities of research support staff.
• Perform other duties as required.

REQUIRED QUALIFICATIONS:

Research Associate I

• Bachelor's degree in Biological or Natural Science, or equivalent experience
• Basic understanding of lab safety and protocols
• Knowledge of Microsoft Office products
• Ability to analyze data in a quantitative and objective manner.
• Ability to work in a team environment.

Research Associate II

• Requirements noted for RA I plus:
• 18 months of relevant research experience with a Bachelor's Degree in Biological or Natural Science or 0 years with a related Master's Degree.

Research Associate III

• Requirements noted for RA I plus:
• 3+ years of relevant research experience with a Bachelor's Degree in Biological or Natural Science or 1 year relevant research experience with a related Master's Degree

Research Associate IV

• Requirements noted for RA I plus:
• 5+ years of relevant research experience with a Bachelor's Degree in Biological or Natural Science or 3+ years relevant research experience with a related Master's degree.

Description

The van Leeuwen lab recently moved from the University of Lausanne (Switzerland) to UMass Chan Medical School, and we are looking for a research associate to strengthen our team at UMass Chan. The candidate will be expected to contribute to our research, which aims to improve our understanding of how mutations can interact to produce unexpected phenotypes. A large part of our research focusses on suppression interactions, in which the deleterious effects of a primary mutation are rescued by another mutation elsewhere in the genome. For human disease genes, suppressors can represent strong targets for therapeutic intervention. Our projects generally include high-throughput genetic screens in either yeast (using robotics) or cultured human cells (using CRISPR-Cas9 gRNA libraries). The candidate will also assist in the training of other lab members and provide general support to the lab. We offer a supportive working environment focused on helping each other, mutual respect, and taking responsibility, and we all share a love for detail and beautiful data.

More information about our lab can be found at https://vanleeuwenlab.com

Please include a cover letter in your application, briefly describing your research experience and explaining why you are interested in this particular position.