Technician B

• Job Type: Support Staff - Union
• Bargaining Unit: SSA
• Regular/Temporary: Temporary
• End Date if Temporary: 1 year
• Hours Per Week: 35
• Standard Work Schedule:
• Building:
• Salary Range: $53,394.17 - $53,394.17 annually

Position Summary

Technician B will work with a team of researchers at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain. The selected candidate will participate in an NIH-funded research project focusing on biomarker discovery and development. This is a 1-year grant-funded position, with the opportunity of appointment extension. The candidate will develop, execute, and maintain bioinformatics pipelines to process and analyze mainly proteomic data from mouse and human biofluid samples. The ideal candidate should have a quantitative background (Computational Biology, Computational Neuroscience, or Bioinformatics), and extensive experience in standard workflows for the analysis of large-scale molecular data, specifically to answer questions about "omics" alterations in human and model system data. In-depth knowledge of at least one flavor of data (genetics, transcriptomics, epigenetics, or proteomics) is required. Proteomics expertise is highly preferred. The candidate should have a good knowledge of programming languages for implementing computational algorithms on large-scale data (R and Python). Wetlab experience with cell biology is a plus for this position. The candidate should be detail oriented and able to multi-task. Good hands, organizational skills, and a keen eye for detail are essential.

Responsibilities

The ideal candidate will be RESPONSIBLE in various essential daily duties, including:

• Processing and preparation of samples for proteomic analysis (mouse and human samples).
• Processing and analysis of proteomic data (downsizing, normalization, imputation, scaling (e.g. z-scores), among other techniques), and visual representation.
• Validation of proteomic "hits" by Western blotting, ELISA-based assays, and in vitro primary neuronal cultures.
• Perform Western blots, protein quantification (BCA, Bradford) assays, Immunoprecipitations assays, among other techniques.
• When required, develop analysis workflows to answer targeted questions about changes in molecular profiles in controls vs. disease state.
• Collaborate with faculty and senior lab members in the performance and analysis of experiments.
• Compile and maintain accurate research records and presenting data in group settings.
• Build their scientific knowledge by reading relevant articles and attending seminars.
• Work under sterile-contained conditions for processing of human and mouse bio-specimens, including blood, Cerebrospinal fluid, and tissue.
• Display initiative and independence in developing novel analysis approaches in response to new questions or insight.
• Perform other related duties and responsibilities as assigned/requested.

Minimum Qualifications

• Requires a bachelor's degree in chemistry, biology, physics or related science or equivalent combination of education, training and experience.

Preferred Qualifications

• Requires a bachelor's or master's degree in computational biology, computational neuroscience, or biostatistics with "omics" experience.

Other Requirements

• Demonstrated programming experience and skills (Python and/or R programming).
• Demonstrated experience with building pipelines for at least one "omics" data modality (genetics, transcriptomics, epigenetics, proteomics).
• Excellent organizational skills in managing/analyzing large datasets.
• Proven ability to effectively plan and organize work activities to meet schedules and deadlines with oversight from supervisor.
• Exhibit initiative, work independently, and be technically proficient in the processes assigned to them.
• Demonstrate initiative in executing tasks, solving problems, and implementing laboratory procedures.
• Willingness to learn new techniques to achieve the overall goal of the project.
• Work with mice (having experience and/or willing to learn colony management, IP injections, etc.).

Equal Opportunity Employer / Disability / Veteran

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