Postdoctoral Researcher

Position Description:



Position Description:

Every day, in ways both big and small, the Medical College of Wisconsin (MCW) is impacting lives for the better. MCW ... changemaking for a healthier Wisconsin. In the role of Postoctoral Fellow you will be working in Biophysics.

The Marinelli Lab at MCW's Biophysics Department explores how cells function at a molecular level, focusing on membrane transport, signaling, and morphological changes. This research relies on state-of-the-art and novel computer simulation methods, rooted in statistical mechanics and machine-learning. Methodological developments constitute an integral part of the lab research agenda and encompass advanced computational approaches to integrate molecular modeling and wet-lab experiments. A hallmark of the lab work, both in understanding mechanisms and developing methods, is its synergistic collaboration with wet-lab researchers. The lab uses this interdisciplinary approach to advance our understanding of proteins and cellular membranes across molecular and supramolecular scales, aiding the discovery of new therapies against diseases.

For more information, see www.mcw.edu/Biophysics.

The laboratory seeks a highly motivated Postdoctoral researcher in the area computational biophysics. The research focus is to study mechanisms and organization of membrane proteins and their interplay with the lipid bilayer dynamics and morphology, particularly within the context of infectious diseases, drug resistance and cancer. This work will primarily rely on molecular simulation methods, encompassing both state-of-the-art techniques and advanced machine-learning approaches.

The role includes contributing to the execution and design of research projects in this area, collaborate with experimental partners, analyze data, present findings at scientific meetings, and prepare manuscripts for peer-reviewed publication.

The lab is committed to providing a rich learning experience while supporting professional growth and transition to career independence.

The position offers a competitive compensation salary aligned with National Institutes of Health (NIH) standards, along with healthcare and other benefits.

Lab members have access to both dedicated and shared high-performance computing resources, including advanced GPU servers reserved for the lab, through the MCW Research Computing Center.

Preferred Schedule:



M-F 8:00 am to 5:00 pm

Position Requirements:

Postdoctoral candidates should have a Ph.D. in Chemistry, Biochemistry, Biophysics, or a related field, with a good publication record. Candidates must be highly motivated, eager to learn, and demonstrate critical thinking and problem-solving skills. Preferred qualifications include significant experience in molecular simulation techniques for studying biomolecular systems, as well as expertise in developing innovative simulation analyses. The ideal candidate will have proficiency in programming languages such as Python or C/C++, along with a solid understanding of protein structure and physical chemistry. Familiarity with Linux-based systems, high-performance computing, and fluency in English are also desirable. Experience with free energy calculations, enhanced sampling methods, deep learning, force-field development, quantum mechanical approaches, and biophysical techniques (e.g., NMR, EPR, FRET, cryo-EM, HDX-MS) will be considered advantageous. Exceptional candidates with alternative computational skills, a strong adaptability, and a keen willingness to learn will also be considered.

Preferred Schedule:

Monday - Friday 8:00-5:00/occasional nights or weekends

• Plan, design and execute complex research studies, procedures and protocols.
• Participate in discovery projects.
• Coordinate research study activities; lead and manage projects.
• Oversee organization, synthesis and analysis of data and findings.
• Prepare scientific reports, outcome findings and scientific manuscripts.
• Participate in meetings with principle investigator and research staff in which you will evaluate/interpret the validity of data, develop methodologies, and design and evaluate lab procedures.
• May oversee the work of laboratory personnel including training and development as well as daily work direction, delegation and establishing priorities.

Specifications

Minimum Required Education: PhD in a scientific field or MD

Preferred Education: Biochemistry, Biophysics, or Computer Science.

Preferred Experience: Training in Computational Biophysics/Chemistry/Engineering/Structural Biology

Field: Biochemistry, Biophysics, or Computer Science.

Why MCW?

• Outstanding Healthcare Coverage, including but not limited to Health, Vision, and Dental. Along with Flexible Spending options
• 403B Retirement Package
• Competitive Vacation and Paid Holidays offered
• Tuition Reimbursement
• Paid Parental Leave
• Pet Insurance
• On campus Fitness Facility, offering onsite classes.
• Additional discounted rates on items such as: Select cell phone plans, local fitness facilities, Milwaukee recreation and entertainment etc.

For a full list of positions see: www.mcw.edu/careers

For a brief overview of our benefits see: https://www.mcw.edu/departments/human-resources/benefits

Eastern Wisconsin is a vibrant, diverse metropolitan area. MCW is intent on attracting, developing, and retaining a diverse workforce and faculty body that reflects the community we serve. We value diversity of backgrounds, experience, thought, and perspectives to advance excellence in science and medicine. MCW is a welcoming campus community with a strong culture of collaboration, partnership, and engagement with our surrounding community. For more information, please visit our institutional website at https://www.mcw.edu/departments/office-of-diversity-and-inclusion.

MCW as an Equal Opportunity Employer and Commitment to Non-Discrimination


The Medical College of Wisconsin (MCW) is an Equal Opportunity Employer. We are committed to fostering a diverse community of outstanding faculty, staff, and students, as well as ensuring equal educational opportunity, employment, and access to services, programs, and activities, without regard to an individual's race, color, national origin, religion, age, disability, sex, gender identity/expression, sexual orientation, marital status, pregnancy, predisposing genetic characteristic, or military status. Employees, students, applicants or other members of the MCW community (including but not limited to vendors, visitors, and guests) may not be subjected to harassment that is prohibited by law or treated adversely or retaliated against based upon a protected characteristic.

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