Intern, Translational Modeling

COMPANY:

At BioCryst, we share a deep commitment to improving the lives of people living with complement-mediated and other rare diseases. For over three decades we've been guided by our passion for not settling for "ordinary" in our quest to develop novel medicines. We leverage our expertise in structure-guided drug design to develop first-in-class or best-in-class oral small-molecule and protein therapeutics, led by the efforts of our team of expert scientists in our Discovery Center of Excellence in Birmingham, Alabama. Our global headquarters is in Durham, North Carolina, our European headquarters is in Dublin, Ireland and our employees span the globe across sites in multiple countries. We are proud of our culture of engagement and accountability that rewards people for innovative thinking and achievement of key objectives. For more information, please visit our website at www.biocryst.com or follow uson LinkedIn and Instagram.

SUMMER INTERNSHIP PROGRAM

The BioCryst Internship Program is your ticket to getting a head start on your career! As an intern, you will gain hands-on, real-world work experience. Our internship program includes:

• 12 weeks of full-time, PAID work experience
• Access to our office in RTP, Frontier Campus
• In-person Summer Internship Orientation
• Professional development workshops and access to LinkedIn Learning
• Expand your professional network through our career connections series
• Social and volunteer activities
• In-person Summer Intern Showcase
• Opportunities to connect with company leaders and MORE!

JOB SUMMARY:

The Translational Modeling Team in Nonclinical Development is seeking an exceptional student in pharmacology, biomedical engineering, chemical engineering, or a related field. The ideal candidate will be passionate about using mathematical modeling approaches to accelerate the design and development of new therapies for patients. This internship offers the opportunity to learn and apply various modeling techniques, including PK/PD, PBPK, QSP, and pathway modeling, to enhance drug development in accordance with MIDD regulatory guidelines. Working in a dynamic and highly collaborative environment with industry leaders, the selected student will gain valuable industrial experience that will significantly boost their future career prospects.

ESSENTIAL DUTIES & RESPONSIBILITIES:

• Design, implement, calibrate, validate, and document mechanistic modeling approaches to address specific MIDD questions.
• Develop custom PBPK models for protein therapeutics, fit-for-purpose QSP models, and detailed pathway models.
• Collaborate with scientists across different departments to ensure the proposed models provide accurate and timely solutions.
• Present modeling results and recommendations at various departmental meetings.
• Must be available to work 30-35 hours per week.

EXPERIENCE & QUALIFICATIONS:

• PhD student in pharmacology, chemical, mechanical or biomedical engineering, biochemistry, physics, applied mathematics, bioinformatics, scientific computing, or related field.
• Proficiency in scientific computing and programming, with a strong preference for experience in Matlab and SimBiology.
• Experience in developing mechanism-based mathematical models of biological systems.
• Excellent written and oral communication skills.
• Scientific curiosity and the ability to provide creative solutions to scientific problems.
• Preference for prior experience with PBPK and QSP modeling workflows.
• Must be in proximity to the Durham/RTP office - on-site presence may be required for meetings and intern program activities

REQUIRED DOCUMENTS

• Resume
• References (2-3)

The statements in this position description are intended to describe the general nature and level of work being performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of responsibilities, duties, and skills required of personnel so classified. The manager may assign additional responsibilities and assignments from time to time.

BioCryst is an equal opportunity employer and is committed to providing equal employment opportunities without regard to age, race, religion, sex, sexual orientation, gender identity, national origin, Veterans status, disability and/or other protected class characteristics. Additionally, BioCryst is committed to achieving its business objectives in compliance with all federal, state and local law.