Principal Scientist/RNA & Vector biology

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we've invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK's long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.

In the plan to create a new hub for mRNA-based vaccine discovery in Cambridge, we are building new laboratories that will be focused on the development of state-of-the-art methods that will be supporting deep product understanding, process and product development, as well as testing of pre-clinical and clinical samples for new mRNA-based vaccines.

As a Principal Scientist, you will be expected to lead and conduct advanced research in the field of RNA vaccines, contributing to the development of innovative vaccine solutions.

Key Responsibilities:

• Lead and conduct advanced research in the field of RNA vaccines, including design, synthesis, and characterization of mRNA vaccines utilizing expertise in RNA biology and virology and new cutting-edge technologies to design best-in-class RNA-based vaccines
• Utilize medium- and high-throughput methodologies for RNA library production and in vitro/in vivo screening of RNA vaccines.
• Develop cell-based assays and characterize RNA modifications and their effects on cell-type specific molecular pathways
• Collaborate with cross-functional teams to translate research findings into vaccine development and guide selection of new vaccine platforms
• Drive effective collaborations with key scientific internal and external stakeholders, utilizing strong scientific, organizational, and interpersonal skills.
• Possesses strong scientific leadership to enable collaboration with key scientific internal and external stakeholders.
• Stay updated with the latest scientific advancements in the field of RNA vaccines and incorporate relevant findings into research.
• Publish research findings in high-impact scientific journals and present at international conferences.
• Ensure compliance with all regulatory standards in the development and testing of RNA vaccines.
• Mentor junior scientists and research associates, fostering a culture of scientific excellence.

Basic Qualifications:

• PhD degree in life sciences or related biotechnology field, with 2+ years of post-doc and/or relevant professional experience; or Master's degree with at least 6 years' experience leading independent research post-master's degree.
• Three or more years of experience developing cell based assays.
• Three or more years of experience with RNA platform technology, RNA biology, and/or virology
• Three or more years of expertise in molecular and cellular biology
• Three or more years of experience in current technologies supporting nucleic acids research, including genome editing technologies
• Three or more years of experience operating liquid-handling robotics systems (Tecan, Hamilton, Echo, etc.)

Preferred Qualifications:

• Prior experience with RNA-based vaccines or therapeutics
• Prior experience in RNA nanotechnology and sequence engineering for RNA-based vaccines or therapeutics
• Experience in 2D RNA structure design, RNA folding and structural elements
• Experience using human cell-based assays to evaluate vaccine or therapeutics candidates
• Prior experience with RNA formulation with lipid nanoparticle (LNP) technology
• Knowledge of current understanding of the innate and adaptive effects of RNA vaccines
• Strong track-record of scientific publications in peer-reviewed journals, with at least 2 first author research manuscripts and/or published patent applications.
• Strong collaboration, communication, and interpersonal skills.

#Vx-Cam

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Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

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