Research Post Doctoral Fellow - Transforming Eosinophilic Esophagitis Frontier Program

A Brief Overview

Assume responsibility for an on-going, innovative research project as a Postdoctoral Fellow at CHOP. Our postdoc experience will broaden your skillset, scientific background, and research capabilities.

CHOP's Commitment to Diversity, Equity, and Inclusion
CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

About the Laboratory

We are looking for a Postdoctoral Research Fellow to join a high-impact research project within a prestigious Frontier Program at the Children's Hospital of Philadelphia (CHOP). This position focuses on the development of innovative lipid nanoparticle (LNP)-based delivery systems for local treatment of eosinophilic esophagitis (EOE).

Project Overview and Environment.

The fellow will lead efforts to design novel delivery platforms for targeting the esophagus. Key strategies include:

• Development of oral delivery systems with increased contact time at the esophageal mucosa.
• Engineering of hydrogels, mucoadhesive gels, or other biomaterials to enhance local retention.
• Integration of devices or other delivery tools to optimize targeting and dosing precision.

This project is part of a collaborative, co-mentored effort involving leaders in drug delivery, esophageal biology, and clinical translation. The fellow will have access to world-class facilities, including advanced formulation and analytical equipment, a state-of-the-art core facility within the CHOP campus, and within the University of Pennsylvania.

Environment & Resources

• Position embedded within CHOP's Frontier Program, which supports transformative, clinically driven research.
• Access to world-class research infrastructure, including advanced formulation, imaging, and in vivo testing cores.
• Opportunities for translational impact, high-impact publications, and career development within one of the top pediatric research institutions globally.

Responsibilities

• Participate in project planning, recording, and evaluation of data.

• Conduct independent scholarly research, developing new methods and protocols under the guidance of a mentor (principal investigator).

• Acquire technical, lab management, and grant writing skills.

• Participate in seminars, lectures, poster sessions, national presentations, and professional workshops.

• Supervise junior lab members.

• Assist with other research projects as needed.

Education

• Required: Doctorate

• Ph.D. in chemistry, chemical engineering, pharmaceutical sciences, materials science, or a related field preferred
• Strong background in polymer chemistry, biomaterials, and/or oral drug delivery preferred
• Experience with lipid-based delivery systems is desirable.
• Knowledge in biology or gastrointestinal physiology is preferred.
• Demonstrated ability to work independently and collaboratively in interdisciplinary teams.