Post-Doctoral Associate

Position & Department Overview

The overall objective of the lab is to understand the mechanisms modulating resistance to therapy and use the knowledge gained from these studies to develop novel therapies for glioblastoma. To this end, we utilize genome-wide screening to identify molecular modifiers of therapy sensitivity, especially to temozolomide (TMZ). We have already identified over six hundred potential druggable modulators of TMZ resistance. The post-doctoral fellow will perform secondary validation to identify the best candidates and use biochemical and pharmacological strategies to evaluate the mechanisms by which these candidates sensitize TMZ in glioblastoma cells in vitro and in vivo. The employer retains the right to change or assign other duties to this position.

Focus of Job Responsibilities

Experimental Design and Therapeutic Evaluation - 60%

* Conduct in vitro and in vivo studies to assess the efficacy of novel therapeutic targets, both alone and in combination with temozolomide and/or radiation.
* Investigate underlying mechanisms of action using a range of biochemical, pharmacological and molecular techniques.

Target Validation and Molecular Engineering - 20%

* Use shRNA/CRISPR gene-targeting approaches to validate novel targets identified through secondary, custom-designed siRNA library screening.

Laboratory Management and Scholarly Contribution - 15%

* Mentor research technologists, students, and/or interns.
* Prepare and contribute to manuscripts for publication.
* Participate in local and national scientific meetings.

Other Duties - 5%

Work Profile
Profile 1, Office Lab-Based - is expected to work primarily on-site in the office/lab. Only occasionally and inconsistently working remotely. Your office will be located at The Hormel Institute in Austin, MN. The Hormel Institute management retains the right to modify flexible work arrangement agreements on a temporary or permanent basis for any reason at any time.

Required Qualifications

* Ph.D., DDS, DVM, MD or equivalent.

Preferred Qualifications

* Experience in molecular and/or cancer biology.
* Experience in next-generation sequencing, CRISPR/Cas9 technology, and in conducting flank and intracranial efficacy studies in animals (mice).

Physical & Environmental Requirements

* Must be comfortable working in environments that may include close contact with animals, animal byproducts, and related materials.
* Exposure to varying temperatures, outdoor environments, and potential odors or airborne particles related to animal care.

The Hormel Institute is an independent biomedical research institution within the University of Minnesota's Research and Innovation Office. Established in 1942, our mission is to conduct research and provide education in the biological sciences with applications in medicine and agriculture, specifically by understanding, treating, and controlling cancer and other chronic diseases. The Hormel Institute serves as a center of technical and educational expertise for the benefit of the local community, the State of Minnesota, and beyond. We are located in the uniquely diverse rural community of Austin, MN, conveniently only 35 miles from Rochester, MN, and 100 miles (1.5 hours) south of Minneapolis/St. Paul. The Hormel Institute is committed to fostering a work environment that promotes inclusive excellence, supportive employee practices, and encourages diversity of thought that drives innovation and creativity in our science.

Pay Range: $62,232 - $72,960 annually; depending on education/qualifications/experience

Please visit the Benefits for Postdoctoral Candidates website for more information regarding benefit eligibility.

• Competitive wages, paid holidays, and generous time off
• Continuous learning opportunities through professional training
• Medical, dental, and pharmacy plans
• Healthcare and dependent care flexible spending accounts
• University HSA contributions
• Disability and life insurance
• Employee wellbeing program
• Financial counseling services
• Employee Assistance Program with eight sessions of counseling at no cost

Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.

Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.

To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-8647.

The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.

The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu

Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.

The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.

At the University of Minnesota, we are proud to be recognized by the Star Tribune as a Top Workplace for 2021, as well as by Forbes as Best Employers for Women and one of America's Best Employers (2015, 2018, 2019, 2023), Best Employer for Diversity (2019, 2020), Best Employer for New Grads (2018, 2019), and Best Employer by State (2019, 2022).