Computational Associate II - Broad Structural Variation Group

Broad Institute
paid time off, paid holidays, 401(k), retirement plan
United States, Massachusetts, Cambridge
Nov 10, 2025
Description & Requirements The Talkowski laboratory, based in the Stanley Center for Psychiatric Research at the Broad Institute and in the Center for Genomic Medicine (CGM) at Massachusetts General Hospital (MGH), is seeking exceptional computational associates to join our Broad Structural Variation Group. The successful candidate will join a team of leading researchers in methods development and computational operations for the discovery, annotation, functional prediction, trait association, and population genetic mapping of structural variation in the human genome. Successful candidates are expected to excel in critical thinking, be quick learners of new analytical approaches, and be capable of applying and developing novel computational methods to solve complex problems. The successful candidate will have a deep background and an established track record in mathematics, programming, and data science. They will have exceptional organization and communication skills and be a collaborative member of an interdisciplinary team. Key Responsibilities: Apply computational methods for structural variant discovery to human genomes. Perform quality control assessments with a deep understanding of the data and the underlying biology. Work closely with biologists to interpret and understand the data and results. Develop new computational methods and improve existing methods for genomics analyses. Track and communicate progress to internal and external stakeholders at meetings and over Slack. Plan and execute on project deliverables, timelines, and budgets. Prepare high-quality publications and oral presentations. Proactively bridge scientific communities. Requirements: Master's + 1 year experience, or Bachelor's + 3 years experience in a computational discipline (e.g., Computational Biology, Bioinformatics, Biostatistics, Bioengineering, Computer Science, Mathematics, Physics, Statistics). Proficiency with coding in at least one programming language, such as Python, R, C++, or Java. Experience with designing computational methods and tools. Excellent oral and written English communication skills. Ability to work independently and to contribute to a team science culture. Desire to meet the milestones and deliverables for the production of national and international community resources such as AoU and gnomAD. The Talkowski Lab is an interdisciplinary group of scientists, technicians, bioinformaticians, computational biologists, and postdoctoral fellows who work together in a mutually supportive and respectful environment. Ideas are freely shared, and contributions are highly valued. We are dedicated to the characterization of genomic variation contributing to human disease, focusing on the relationship between genome structure and function. The lab integrates molecular and computational genomics methods to investigate the genetic architecture of neuropsychiatric disorders and to develop new technologies for translational applications in genetic diagnostics. The lab has represented a hub of novel gene and variant discovery and functional genomics modeling in common complex and rare Mendelian disorders. Please include a cover letter along with your resume. The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law. At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits. The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations. Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.