New

Research Scientist I- Cell Biologist/High Throughput Screening

Broad Institute
paid time off, paid holidays, 401(k), retirement plan
United States, Massachusetts, Cambridge
Mar 02, 2026
Description & Requirements We're looking for a passionate and skilled Cell Biologist with High Throughput Screening experience to join our CDoT Collaborative Screening team. Reporting to an Associate Director, you'll be a key member of our multidisciplinary teams, helping to drive the development and execution of predominantly cell-based high throughput screens. Your work will directly empower target validation, assay development, hit discovery and validation. Ideally, you have experience with a variety of assay formats within a drug discovery or therapeutics context. Key Responsibilities * Independently design and execute cell-based assays for drug discovery projects, including both genetic and small molecule screening in various high throughput formats. * Culture and maintain diverse cell lines and primary cells with a high degree of precision. * Collaborate,coordinate and communicate with cross-functional teams to advance therapeutic projects and ensure that research plans, timelines, and deliverables are met. * Analyze, interpret,explain and present experimental data, research plans and results to both internal teams and external collaborators. * Innovate new cellular assay methods and contribute to a fast-paced, dynamic research environment. * Supervise, train and mentor junior members of the team. Qualifications Required Qualifications: Master's degree with 5-7 years experience in cell biology, chemical biology, or high throughput screening Demonstrated in-depth experience in culturing, deriving, and maintaining various cell lines. Proven ability to work both collaboratively within a team and independently to meet project goals; makes data-driven decisions for forward progress Maintain detailed experimental records, documentation, and written protocols Excellent communication, organization, and time management skills. Must show strong ability to be flexible, to adapt and effectively manage changes in a fast-paced dynamic environment and troubleshoot Preferred Qualifications: Experience with the development and execution of plate-based assays, such as Cell Titer-Glo viability assay, immunofluorescence staining and biochemical assays, as well as high-throughput screening and automation. Experience with advanced techniques such as high-content imaging or molecular biology (e.g., qPCR, western blotting, ELISA). Experience with FLIPR (Fluorescence Imaging Plate Reader) assays to measure intracellular calcium flux, membrane potential, and ion channel activity. Ability to mentor junior trainees The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law. At Broad, your base pay is just one part of a comprehensive total rewards package. From day one, this role offers a competitive benefits package including medical, dental, vision, life, and disability insurance; a 401(k) retirement plan; flexible spending and health savings accounts; at least 13 paid holidays; winter closure; paid time off; parental and family care leave; and an employee assistance program, among other Broad benefits. The Broad Institute is an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, national origin, religion, age, color, sex, disability, protected veteran status, or any other characteristic protected by local, state, or federal laws, rules, or regulations. Should you need a reasonable accommodation to complete the application or interview process, please contact recruiting@broadinstitute.org for assistance.